LY294002 (CAS 154447-36-6) | Cayman Chemical
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LY294002

Item № 70920
CAS № 154447-36-6
Purity ≥98%
product image
                (CAS 154447-36-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $34.00 0.00
     10 mg $65.00 0.00
     25 mg $153.00 0.00
     50 mg $272.00 0.00

Pricing updated 2018-12-10. Prices are subject to change without notice.

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 µM.1

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Technical Information
Formal Name
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
CAS Number
154447-36-6
Molecular Formula
C19H17NO3
Formula Weight
307.3
Purity
≥98%
Formulation
A crystalline solid
λmax
223, 302 nm
SMILES
O=c1cc(oc2c(cccc12)c1ccccc1)N1CCOCC1
InChI Code
InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI Key
CZQHHVNHHHRRDU-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Vlahos, C.J., Matter, W.F., Hui, K.Y., et al. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) The Journal of Biological Chemisty 269, 5241-5248 (1994).

Product Citations

McDougle, D.R., Watson, J.E., Abdeen, A.A., et al. Anti-inflammatory ω-3 endocannabinoid epoxides Proc. Natl. Acad. Sci. U.S.A. 114(30), E6034-E6043 (2017).

Yeh, H.-H., Kong, W., Hooper, K.l., et al. Differential effects of IFN-β on IL-12, IL-23, and IL-10 expression in TLR-stimulated dendritic cells J. Leukoc. Biol. 98(5), 689-702 (2015).

Reinke, E.N., Ekoue, D.N., Bera, S., et al. Translational regulation of GPx-1 and GPx-4 by the mTOR pathway PLOS One 9(4), e93472 (2014).

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