A potent, selective PPARγ ligand
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Ciglitazone

Item No. 71730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
CAS Number
74772-77-3
Synonyms
  • ADD 3878
  • U-63287
Molecular Formula
C18H23NO3S
Formula Weight
333.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 21 mg/mlDMSO:PBS (pH 7.2) (1:4): 400 µg/mlEthanol: 29 mg/ml
λmax
228, 279, 284 nm
SMILES
O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCCCC1
InChi Code
InChI=1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
InChi Key
YZFWTZACSRHJQD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $61

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    25 mg

    $167

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    100 mg

    $605

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    250 mg

    $1,060

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ciglitazone is an antidiabetic drug of the thiazolidinedione structural class. Ciglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with an EC50 of 3.0 µM.1 Ciglitazone is active in vivo as an anti-hyperglycemic agent in the ob/ob mouse model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem. 39(3), 665-668 (1996).

    Product Citations

    Aleshin, S., Grabeklis, S., Hanck, T., et al. Peroxisome proliferator-activated receptor (PPAR)-g positively controls and PPARa negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARb/d via mutual control of PPAR expression levels. Mol. Pharmacol. 76(2), 414-424 (2009).