A farnesoid X receptor antagonist
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(Z)-Guggulsterone

Item No. 71800

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
pregna-4,17Z(20)-diene-3,16-dione
CAS Number
39025-23-5
Molecular Formula
C21H28O2
Formula Weight
312.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 0.25 mg/mlEthanol: 1 mg/ml
SMILES
C/C=C1\C(=O)CC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]\12C
InChi Code
InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15?,17?,18?,20-,21+/m0/s1
InChi Key
WDXRGPWQVHZTQJ-XCTJHIRPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    (Z)-Guggulsterone demonstrates antitumor-promoting effects inhibiting both constitutive and interleukin-6-induced STAT3 activation in human multiple myeloma cells and suppressing the VEGF-VEGF/R2-Akt signaling axis in DU145 human prostate cancer cells.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahn, K.S., Sethi, G., Sung, B., et al. Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. Cancer Res. 68(11), 4406-4415 (2008).

    2. Xiao, D., and Singh, S.V. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol. Cancer Ther. 7(1), 171-180 (2008).