An antagonist of metabotropic glutamate receptors
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ACPT-II

Item No. 78020

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-1α,2α,4β-cyclopentanetricarboxylic acid
CAS Number
195209-04-2
Molecular Formula
C8H11NO6
Formula Weight
217.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 0.25 mg/mlPBS pH 7.2: 10 mg/ml
SMILES
OC(=O)C1CC(N)(CC1C(=O)O)C(=O)O
InChi Code
InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)
InChi Key
FERIKTBTNCSGJS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $143

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    10 mg

    $236

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    50 mg

    $934

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    Product Description

    ACPT-II is a general competitive antagonist of metabotropic glutamate (mGlu) receptors. The KB values for mGlu1a, mGlu2, and mGlu4a receptors are 115, 88, and 77 µM, respectively.1 It binds to the large extracellular domain called a Venus flytrap module, where agonists bind.2 ACPT-II is a stereoisomer of the group III mGlu receptor-selective antagonist, ACPT-I.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Acher, F.C., Tellier, F.J., Azerad, R., et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: New tools to discriminate between metabotropic glutamate receptor subtypes. J. Med. Chem. 40, 3119-3129 (1997).

    2. Bessis, A.S., Ronard, P., Gaven, F., et al. Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc. Natl. Acad. Sci. USA 99(17), 11097-11102 (2002).