Donor of both NO and superoxide
Related Products
Pro-drug Form(s)
82200Molsidomine
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SIN-1 (chloride)

Item No. 82220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride
CAS Number
16142-27-1
Synonyms
  • Linsidomine
  • 3-Morpholino-sydnonimine
Molecular Formula
C6H11N4O2 • Cl
Formula Weight
206.6
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 9 mg/mlEthanol: 8 mg/mlPBS pH 7.2: 10 mg/ml
λmax
253, 296 nm
SMILES
NC1=C[N+](N2CCOCC2)=NO1.[Cl-]
InChi Code
InChI=1S/C6H11N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5H,1-4,7H2;1H/q+1;/p-1
InChi Key
ZRFWHHCXSSACAW-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $36

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    50 mg

    $150

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    100 mg

    $247

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    500 mg

    $1,056

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    Product Description

    As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rosenkranz, B., Winkelmann, B.R., and Parnham, M.J. Clinical pharmacokinetics of molsidomine. Clin. Pharmacokinet. 30(5), 372-384 (1996).

    2. Lomonosova, E.E., Kirsch, M., Rauen, U., et al. The critical role of hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide. Free Radic. Biol. Med. 24, 522-528 (1998).

    3. Nishikawa, M., Kanamori, M., and Hidaka, H. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J. Pharmacol. Exp. Ther. 220, 183-190 (1982).

    Product Citations

    Schildknecht, S., Weber, A., Gerding, H.R., et al. The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite. Curr. Med. Chem. 21(3), 365-376 (2014).