A potent, reversible inhibitor of histone deacetylases
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Trichostatin A

Item No. 89730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
CAS Number
58880-19-6
Synonyms
  • TSA
Molecular Formula
C17H22N2O3
Formula Weight
302.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M HCl: 1.3 mg/mlDMF: 2 mg/mlDMSO: 2 mg/ml
λmax
265, 340 nm
SMILES
CN(C)C1=CC=C(C([C@H](C)/C=C(C)/C=C/C(N(O)[H])=O)=O)C=C1
InChi Code
InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChi Key
RTKIYFITIVXBLE-QEQCGCAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.1 Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoshikawa, Y., Kwon, H.J., Yoshida, M., et al. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Exp. Cell Res. 214, 189-197 (1994).

    2. Taunton, J., Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272(5260), 408-411 (1996).

    Product Citations

    Kaliszewski, M., Kennedy, A.K., Blaes, S.L., et al. SOD1 lysine 123 acetylation in the adult central nervous system. Front. Cell. Neurosci. 10, 287 (2016).