An antioxidant
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Isomer(s)
3322520-Deoxyingenol
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Carnosic Acid

Item No. 89820

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4aR(2H)-phenanthrenecarboxylic acid
CAS Number
3650-09-7
Synonyms
  • Salvin
Molecular Formula
C20H28O4
Formula Weight
332.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
284 nm
SMILES
OC1=C([C@]2(C(O)=O)C(CC3)C(C)(C)CCC2)C3=CC(C(C)C)=C1O
InChi Code
InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)
InChi Key
QRYRORQUOLYVBU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Carnosic acid is an active diterpene found in rosemary (R. officinalis) and common sage (S. officinalis). Its antioxidant properties include inhibition of lipid peroxidation and scavenging of peroxyl radicals.1 Carnosic acid has been shown to be cytotoxic towards various human cancer cell lines, reducing cell viability to 13-30% 48 hours after application at a concentration of 6.25 µg/ml.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aruoma, O.I., Halliwell, B., Aeschbach, R., et al. Antioxidant and pro-oxidant properties of active rosemary constituents: Carnosol and carnosic acid. Xenobiotica 22(2), 257-268 (1992).

    2. Yesil-Celiktas, O., Sevimli, C., Bedir, E., et al. Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum. Nutr. 65(2), 158-163 (2010).

    Product Citations

    Trachtenberg, A., Muduli, S., Sidoryk, K., et al. Synergistic cytotoxicity of methyl 4-hydroxycinnamate and carnosic acid to acute myeloid leukemia cells via calcium-dependent apoptosis induction. Front. Pharmacol. 10, 507 (2019).