An inhibitor of CYP1A2
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Furafylline

Item No. 9000058

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-1H-purine-2,6-dione
CAS Number
80288-49-9
Molecular Formula
C12H12N4O3
Formula Weight
260.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 0.5 mg/ml
λmax
272 nm
SMILES
O=C1C2=C(N=C(C)N2)N(CC3=CC=CO3)C(N1C)=O
InChi Code
InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14)
InChi Key
KGQZGCIVHYLPBH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $90

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    1 mg

    $142

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    5 mg

    $349

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    Product Description

    Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 = 0.07 µM), demonstrating little effect on other CYP isoforms including 2D1, 2C, 3A, or 1A1.1 It was originally introduced as a bronchodilator with extended duration compared to theophylline, but then subsequently reported to inhibit the oxidation of caffeine (Item No. 14118), a reaction catalyzed by CYP1A2.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sesardic, D., Boobis, A.R., Murray, B.P., et al. Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. Br. J. Clin. Pharmacol. 29(6), 651-663 (1990).

    2. Tarrus, E., Cami, J., Roberts, D.J., et al. Accumulation of caffeine in healthy volunteers treated with furafylline. Br. J. Clin. Pharmacol. 23(1), 9-18 (1987).