A metabolite of PGA1
Related Products
Parent Compound(s)
10010Prostaglandin A1
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15-keto Prostaglandin A1

Item No. 9000142

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,15-dioxo-prosta-10,13E-dien-1-oic acid
CAS Number
61600-67-7
Synonyms
  • 15-keto PGA1
Molecular Formula
C20H30O4
Formula Weight
334.5
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
228 nm
SMILES
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/C(CCCCC)=O)C=C1
InChi Code
InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-16,18H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,18+/m0/s1
InChi Key
YKXHFAJZOFTAOC-DTXSUPOZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $72

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    1 mg

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    5 mg

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    Product Description

    Prostaglandin A1 (PGA1) (Item No. 10010) was first isolated as a dehydration product of the PGE1 (Item No. 13010) compounds found in human semen.1 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase.2 It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations.2 15-keto PGA1, given at a concentration of 6 µM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamberg, M., and Samuelsson, B. Prostaglandins in human seminal plasma. The Journal of Biological Chemisty 241(2), 257-263 (1966).

    2. Ody, C., Dieterle, Y., Wand, I., et al. PGA1 and PGF2α metabolism by pig pulmonary endothelium, smooth muscle, and fibroblasts. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 46(2), 211-216 (1979).

    3. Gross, K.B., and Gillis, C.N. Comparison of the pulmonary vascular response to prostglandin A1, prostaglandin F2α and angiotensin II; metabolism of PGA1 in lung. Life Sci. 19(11), 1653-1661 (1976).