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Spironolactone

Item No. 9000324

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • NSC 150399
  • SC-9420
Technical Information
Formal Name
(7α,17α)-7-(acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid-γ-lactone
CAS Number
52-01-7
Molecular Formula
C24H32O4S
Formula Weight
416.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 0.1 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
236 nm
SMILES
O=C(CC1)O[C@@]21CC[C@@]3([H])[C@]4([H])[C@H](SC(C)=O)CC5=CC(CC[C@]5(C)[C@@]4([H])CC[C@@]32C)=O
InChi Code
InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
InChi Key
LXMSZDCAJNLERA-ZHYRCANASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Spironolactone (Item No. 9000324) is an analytical reference standard categorized as a steroid.1,2 It is a diuretic that has been abused as a performance-enhancing drug and masking agent in sports doping.3 This product is intended for research and forensic applications

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chun, T.Y., Bloem, L.J., and Pratt, J.H. Aldosterone inhibits inducible nitric oxide synthase in neonatal rat cardiomyocytes. Endocrinology 144(5), 1712-1717 (2003).

    2. Larik, F.A., Saaed, A., Shahzad, D., et al. Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives. Steroids 118, 76-92 (2017).

    3. Cadwallader, A.B., de la Torre, X., Tieri, A., et al. The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: Pharmacology, toxicology and analysis. Br. J. Pharmacol. 161(1), 1-16 (2010).