Internal standard for the quantification of GW 9662
Related Products
Unlabeled Version(s)
70785GW 9662
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GW 9662-d5

Item No. 9000497

Technical Information
Formal Name
2-chloro-5-nitrobenzanilide-10,11,12,13,14-d5
Molecular Formula
C13H4ClD5N2O3
Formula Weight
Purity
≥99% deuterated forms (d1-d5)
Formulation
A crystalline solid
DMF: 35 mg/mlDMF:PBS(pH7.2) (1:2): >0.5 mg/mlDMSO: 33 mg/mlEthanol: 2 mg/ml
λmax
260 nm
SMILES
ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O
InChi Code
InChI=1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)/i1D,2D,3D,4D,5D
InChi Key
DNTSIBUQMRRYIU-RALIUCGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.1 It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bendixen, A.C., Shevde, N.K., Dienger, K.M., et alIL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1. Proc. Natl. Acad. Sci. USA 98, 2443-2448 (2001).