A PPARγ antagonist
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Labeled Version(s)
9000497GW 9662-d5
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GW 9662

Item No. 70785

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-5-nitrobenzanilide
CAS Number
22978-25-2
Molecular Formula
C13H9ClN2O3
Formula Weight
276.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 35 mg/mlDMF:PBS (7.2 pH) (1:2): 0.5 mg/mlDMSO: 33 mg/mlEthanol: 2 mg/ml
λmax
261 nm
SMILES
O=C(C1=CC([N+]([O-])=O)=CC=C1Cl)N([H])C2=CC=CC=C2
InChi Code
InChI=1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
InChi Key
DNTSIBUQMRRYIU-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $62

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    10 mg

    $97

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    25 mg

    $207

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    Product Description

    GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.1 It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Davies, S.S., Pontsler, A.V., Marathe, G.K., et al. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonists. The Journal of Biological Chemisty 276(19), 16015-16023 (2001).

    2. Bendixen, A.C., Shevde, N.K., Dienger, K.M., et al. IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1. Proc. Natl. Acad. Sci. USA 98, 2443-2448 (2001).

    Product Citations

    Qi, W., Clark, J.M., Timme-Laragy, A.R., et al. Perfluorobutanesulfonic acid (PFBS) induces fat accumulation in HepG2 human hepatoma. Toxicol. Environ. Chem. 102(10), 585-606 (2020).

    Yousefi, B., Azimi, A., Majidinia, M., et al. Balaglitazone reverses P-glycoprotein-mediated multidrug resistance via upregulation of PTEN in a PPARγ-dependent manner in leukemia cells. Tumour Biol. 39(10), (2017).

    McDougle, D.R., Watson, J.E., Abdeen, A.A., et al. Anti-inflammatory ω-3 endocannabinoid epoxides. Proc. Natl. Acad. Sci. USA 114(30), E6034-E6043 (2017).

    Díaz-Alonso, J., Paraíso-Luna, J., Navarrete, C., et al. VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease. Sci. Rep. 6, 29789 (2016).

    Bain, G., Shannon, K.E., Huang, F., et al. Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J. Pharmacol. Exp. Ther. 360(1), 1-13 (2016).

    Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation. Front. Bioeng. Biotechnol. 4(27), (2016).

    Malaviya, A., and Sylvester, P.W. Synergistic antiproliferative effects of combined g-tocotrienol and PPARg antagonist treatment are mediated through PPARg-independent mechanisms in breast cancer cells. PPAR Res. 2014(439146), (2014).

    Hsu, W.-H., Liao, T.-H., Lee, B.-H., et al. Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation. J. Funct. Foods 5(1), (2012).

    Aleshin, S., Grabeklis, S., Hanck, T., et al. Peroxisome proliferator-activated receptor (PPAR)-g positively controls and PPARa negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARb/d via mutual control of PPAR expression levels. Mol. Pharmacol. 76(2), 414-424 (2009).