An atypical antipsychotic
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Lurasidone

Item No. 9000570

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
CAS Number
367514-87-2
Molecular Formula
C28H36N4O2S
Formula Weight
492.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
205, 318 nm
SMILES
[H][C@@]1(C2=O)[C@]([C@H]3CC[C@@H]1C3)([H])C(N2C[C@@H]4CCCC[C@H]4CN5CCN(C6=NSC7=C6C=CC=C7)CC5)=O
InChi Code
InChI=1S/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1
InChi Key
PQXKDMSYBGKCJA-CVTJIBDQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $213

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    10 mg

    $303

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    25 mg

    $454

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    Product Description

    Lurasidone is an atypical antipsychotic that binds to dopamine D2, serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT1A, and 5-HT7, and α2C-adrenergic receptors (Kis = 1.68, 2.03, 6.75, 0.495, and 10.8 nM, respectively).1 In vivo, pre-training administration of lurasidone (1 and 3 mg/kg) reverses impairment in step-through latency and passive avoidance in a foot shock test induced by MK-801 (Item No. 10009019) in rats. It reverses MK-801-induced learning impairment in the Morris water maze as well as reference and working memory impairment in the radial arm maze in rats.2 Lurasidone also decreases immobility in the tail suspension and forced swim tests, indicating antidepressant-like activity in mice.3 Formulations containing lurasidone have been used in the treatment of schizophrenia and mood disorders.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ishiyama, T., Tokuda, K., Ishibashi, T., et al. Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test. Eur. J. Pharmacol. 572(2-3), 160-170 (2007).

    2. Enomoto, T., Ishibashi, T., Tokuda, K., et al. Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats. Behav. Brain Res. 186(2), 197-207 (2008).

    3. Cates, L.N., Roberts, A.J., Huitron-Resendiz, S., et al. Effects of lurasidone in behavioral models of depression. Role of the 5-HT7 receptor subtype. Neuropharmacology 70, 211-217 (2013).