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JWH 081 N-(5-hydroxypentyl) metabolite

Item No. 9000768

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1-(5-hydroxypentyl)-1H-indol-3-yl](4-methoxy-1-naphthalenyl)-methanone
CAS Number
1427325-66-3
Molecular Formula
C25H25NO3
Formula Weight
387.5
Purity
≥95%
Formulation
A 10 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:5): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
213, 320 nm
SMILES
O=C(C1=CN(CCCCCO)C2=C1C=CC=C2)C3=C4C(C=CC=C4)=C(OC)C=C3
InChi Code
InChI=1S/C25H25NO3/c1-29-24-14-13-21(18-9-3-4-11-20(18)24)25(28)22-17-26(15-7-2-8-16-27)23-12-6-5-10-19(22)23/h3-6,9-14,17,27H,2,7-8,15-16H2,1H3
InChi Key
MCDCEPNRUDLEJP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.1 Hydroxylated and glucuronidated metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.2,3,4 JWH 081 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 081 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 081 that would be detectable both in serum and in urine. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product. Forensic Toxicol. 27(2), 61-66 (2009).

    2. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS. Anal. Bioanal. Chem. 386(5), 1345-1355 (2006).

    3. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).

    4. Moran, C.L., Le, V.H., Chimalakonda, K.C., et al. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine. Anal. Chem. 83(11), 4228-4236 (2011).

    Product Citations

    Cho, B., Cho, H.S., Kim, J., et al. Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair. Forensic Sci. Int. 306, 110058 (2020).