A vanin-1 inhibitor
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RR6

Item No. 9001411

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)-butanamide
CAS Number
1351758-37-6
Molecular Formula
C16H23NO4
Formula Weight
293.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: SolubleMethanol: Soluble
SMILES
O=C(CC1=CC=CC=C1)CCNC([C@@H](C(C)(CO)C)O)=O
InChi Code
InChI=1S/C16H23NO4/c1-16(2,11-18)14(20)15(21)17-9-8-13(19)10-12-6-4-3-5-7-12/h3-7,14,18,20H,8-11H2,1-2H3,(H,17,21)/t14-/m0/s1
InChi Key
PTVUGLNOPRZQEY-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $65

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    5 mg

    $277

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    10 mg

    $455

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    25 mg

    $731

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    Cayman Chemical
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    Product Description

    RR6 is an inhibitor of the pantetheinase vanin-1 (IC50 = 0.54 µM for the recombinant human enzyme) and is a derivative of the CoA precursor D-pantothenic acid (Item No. 17288).1 It is selective for vanin-1 over biotinidase, cathepsin B, cathepsin L, and papain (IC50s = >200 µM for all). RR6 is active against P. falciparum (IC50 = 14.5 µM).2 It reduces plasma levels of cholesterol and increases plasma levels of free fatty acids in fasted rats when administered in the drinking water at 3 mg/ml.1 RR6 decreases neointima formation and macrophage infiltration in aortic allografts in a rat model of transplant vasculopathy.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jansen, P.A., van Diepen, J.A., Ritzen, B., et al. Discovery of small molecule vanin inhibitors: New tools to study metabolism and disease. ACS Chem. Biol. 8(3), 530-534 (2013).

    2. Pett, H.E., Jansen, P.A.M., Hermkens, P.H.H., et al. Novel pantothenate derivatives for anti-malarial chemotherapy. Malar. J. 14, 169 (2015).

    3. Wedel, J., Jansen, P.A.M., Botman, P.N.M., et al. Pharmacological inhibition of vanin activity attenuates transplant vasculopathy in rat aortic allografts. Transplantation 100(8), 1656-1666 (2016).