A potential derivative of agmatine
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N-Acetylagmatine (acetate salt)

Item No. 9001534

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-guanidinobutyl)acetamide acetate
Synonyms
  • Monoacetylagmatine
Molecular Formula
C7H16N4O • C2H4O2
Formula Weight
232.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
NC(NCCCCNC(C)=O)=N.CC(O)=O
InChi Code
InChI=1S/C7H16N4O.C2H4O2/c1-6(12)10-4-2-3-5-11-7(8)9;1-2(3)4/h2-5H2,1H3,(H,10,12)(H4,8,9,11);1H3,(H,3,4)
InChi Key
VVLRLWUBZUFCRZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $145

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    10 mg

    $256

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    50 mg

    $1,038

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    Cayman Chemical
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    Product Description

    Agmatine is a natural polyamine formed by the enzymatic decarboxylation of arginine.1 It can be converted to putrescine by agmatinase or to guanidinobutyric acid by diamine oxidase and aldehyde dehydrogenase. Agmatine has numerous modulatory actions, particularly in pathways related to diabetes, immunity, and neurophysiology.1 N-Acetylagmatine is a potential monoacetylated derivative of agmatine. The enzyme-mediated acetylation of polyamines is commonly considered a degradative step, with monoacetylated polyamines detected in the urine.1,2,3 However, monoacetylated polyamines can stimulate diamine oxidase activity, suggesting that N-acetylagmatine might have physiologically important actions.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Piletz, J.E., Aricioglu, F., Cheng, J.T., et al. Agmatine: Clinical applications after 100 years in translation. Drug Discov. Today 18(17-18), 880-893 (2013).

    2. van den Berg, G.A., Muskiet, F.A., Kingma, A.W., et al. Simultaneous gas-chromatographic determination of free and acetyl-conjugated polyamines in urine. Clin. Chem. 32(10), 1930-1937 (1986).

    3. Seiler, N., and Al-Therib, M.J. Putrescine catabolism in mammalian brain. Biochem. J. 144(1), 29-35 (1974).

    4. Perin, A., Sessa, A., and Desiderio, M.A. Response of tissue diamine oxidase activity to polyamine administration. Biochem. J. 234(1), 119-123 (1986).