Induces pluripotency in somatic cells
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RSC-133

Item No. 9001839

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide
CAS Number
1418131-46-0
Molecular Formula
C18H15N3O2
Formula Weight
305.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
λmax
224, 277, 340, 351 nm
SMILES
O=C(NC1=CC=CC(C(N)=O)=C1)/C=C/C2=CNC3=C2C=CC=C3
InChi Code
InChI=1S/C18H15N3O2/c19-18(23)12-4-3-5-14(10-12)21-17(22)9-8-13-11-20-16-7-2-1-6-15(13)16/h1-11,20H,(H2,19,23)(H,21,22)/b9-8+
InChi Key
HYUDSQGICKAEGE-CMDGGOBGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $99

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    10 mg

    $178

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    25 mg

    $389

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    Product Description

    RSC-133 is an indole compound that promotes the reprogramming of human somatic cells to pluripotent stem cells.1 Specifically, when used at 10 μM with four standard reprogramming factors, it increases the number of human foreskin fibroblasts that express the stem cell marker alkaline phosphatase.1 RSC-133 induces pluripotency by both down-regulating inducers of cellular senescence and inhibiting DNA methyltransferase and histone deacetylase activities.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, J., Xia, Y., Son, M.Y., et al. A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Angew. Chem. Int. Ed. 51(50), 12509-12513 (2012).