An Analytical Reference Standard
Related Products
Parent Compound(s)
20374Diphenoxylate (hydrochloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Difenoxin (hydrochloride)

Item No. 9001921

Restricted Product (Schedule I)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Diphenoxylic Acid
  • R 15403
Technical Information
Formal Name
1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid, monohydrochloride
CAS Number
35607-36-4
Molecular Formula
C28H28N2O2 • HCl
Formula Weight
461.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 0.1 mg/mlMethanol: 1 mg/ml
SMILES
O=C(O)C1(C2=CC=CC=C2)CCN(CCC(C3=CC=CC=C3)(C#N)C4=CC=CC=C4)CC1.Cl
InChi Code
InChI=1S/C28H28N2O2.ClH/c29-22-28(24-12-6-2-7-13-24,25-14-8-3-9-15-25)18-21-30-19-16-27(17-20-30,26(31)32)23-10-4-1-5-11-23;/h1-15H,16-21H2,(H,31,32);1H
InChi Key
VMIZTXDGZPTKIK-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $90

    Add

    1 mg

    $168

    Add

    5 mg

    $696

    Add
    Cayman Chemical
    Cayman Spectral Library

    Our free, searchable, GC-MS spectral database contains 70eV EI mass spectral data of 2,000+ of Cayman’s forensic drug standards.

    DOWNLOAD THE DATABASE
    Product Description

    Difenoxin is the active metabolite of diphenoxylate.1,2 It is thought to act primarily as a preferential agonist of enteric opiate receptors.2,3 This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jackson, L.S., and Stafford, J.E. The evaluation and application of a radioimmunoassay for the measurement of diphenoxylic acid, the major metabolite of diphenoxylate hydrochloride (Lomotil), in human plasma. J. Pharmacol. Methods 18(3), 189-197 (1987).

    2. De Luca, A., and Coupar, I.M. Difenoxin and loperamide: Studies on possible mechanisms of intestinal antisecretory action. Naunyn Schmiedebergs Arch. Pharmacol. 347(2), 231-237 (1993).

    3. Coupar, I.M. The peristaltic reflex in the rat ileum: Evidence for functional μ- and δ-opiate receptors. J. Pharm. Pharmacol. 47(8), 643-646 (1995).