A CB2 receptor agonist
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MCHB-1

Item No. 9001949

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(cyclohexylmethyl)-2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-1H-benzimidazole-5-carboxamide
CAS Number
1046140-32-2
Synonyms
  • N-Methylcyclohexyl benzimidazole analog 1
Molecular Formula
C28H37N3O2
Formula Weight
447.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
217, 281 nm
SMILES
CCOC(C=C1)=CC=C1CC2=NC3=CC(C(N(CC)CC)=O)=CC=C3N2CC4CCCCC4
InChi Code
InChI=1S/C28H37N3O2/c1-4-30(5-2)28(32)23-14-17-26-25(19-23)29-27(31(26)20-22-10-8-7-9-11-22)18-21-12-15-24(16-13-21)33-6-3/h12-17,19,22H,4-11,18,20H2,1-3H3
InChi Key
WRVZBXHTUOPQJS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    MCHB-1 is a potent agonist of the human cannabinoid 2 (CB2) receptor (EC50 = 0.52 nM) that shows high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively).1 Similar benzimidazole compounds significantly reduce peripheral pain with reduced central nervous system side effects in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pagé, D., Balaux, E., Boisvert, L., et al. Novel benzimidazole derivatives as selective CB2 agonists. Bioorg. Med. Chem. Lett. 18(13), 3695-3700 (2008).

    2. Yu, X.H., Cao, C.Q., Martino, G., et al. A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain. Pain 151(2), 337-344 (2010).