Pricing updated 2019-07-21. Prices are subject to change without notice.
WH-4-023 is a selective inhibitor of the Src family of non-receptor tyrosine kinases (IC50s = 2 and 6 nM for Lck and Src, respectively).1,2 It inhibits the related kinases p38α and KDR at >300-fold higher concentrations (IC50s = 1.3 and 0.65 µM, respectively).1 At 1 µM, it has been used in combination with PD 0325901 (Item No. 13034), CHIR99021 (Item No. 13122), and SB-590885 (Item No. 16643) to support self-renewal of naïve human embryonic stem cells.3
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Martin, M.W., Newcomb, J., Nunes, J.J., et al. Novel 2-
Moroco, J.A., Baumgartner, M.P., Rust, H.L., et al. A discovery strategy for selective inhibitors of c-
3. Theunissen, T.W., Powell, B.E., Wang, H., et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency Cell Stem Cell 15(4), 471-487 (2014).