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WH-4-023

Item № 9002067
CAS № 837422-57-8
Purity ≥98%
product image
                (CAS 837422-57-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $31.00 0.00
     5 mg $93.00 0.00
     10 mg $140.00 0.00
     25 mg $310.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description

WH-4-023 is a selective inhibitor of the Src family of non-receptor tyrosine kinases (IC50s = 2 and 6 nM for Lck and Src, respectively).1,2 It inhibits the related kinases p38α and KDR at >300-fold higher concentrations (IC50s = 1.3 and 0.65 µM, respectively).1 At 1 µM, it has been used in combination with PD 0325901 (Item No. 13034), CHIR99021 (Item No. 13122), and SB-590885 (Item No. 16643) to support self-renewal of naïve human embryonic stem cells.3

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Technical Information
Formal Name
N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-carbamic acid, 2,6-dimethylphenyl ester
CAS Number
837422-57-8
Molecular Formula
C32H36N6O4
Formula Weight
568.7
Purity
≥98%
Formulation
A crystalline solid
λmax
284 nm
SMILES
COC1=CC=C(N(C(OC2=C(C)C=CC=C2C)=O)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3)C(OC)=C1
InChI Code
InChI=1S/C32H36N6O4/c1-22-7-6-8-23(2)30(22)42-32(39)38(27-14-13-26(40-4)21-28(27)41-5)29-15-16-33-31(35-29)34-24-9-11-25(12-10-24)37-19-17-36(3)18-20-37/h6-16,21H,17-20H2,1-5H3,(H,33,34,35)
InChI Key
NBTNHSGBRGTFJS-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Martin, M.W., Newcomb, J., Nunes, J.J., et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity J.Med.Chem. 49(16), 4981-4991 (2006).

2. Moroco, J.A., Baumgartner, M.P., Rust, H.L., et al. A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding region Chem.Biol.Drug Des. 86(2), 144-155 (2015).

3. Theunissen, T.W., Powell, B.E., Wang, H., et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency Cell Stem Cell 15(4), 471-487 (2014).

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