Androgen receptor antagonist
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HE-3235

Item No. 9002769

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5α,17α)-pregn-20-yne-3,17-diol
CAS Number
183387-50-0
Synonyms
  • Apoptone
  • 17α-Ethynyl-5α-androstane-3α,17ß-diol
Molecular Formula
C21H32O2
Formula Weight
316.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/mlEthanol: 10 mg/ml
SMILES
C[C@@]12[C@](CC[C@]2(C#C)O)([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC1
InChi Code
InChI=1S/C21H32O2/c1-4-21(23)12-9-18-16-6-5-14-13-15(22)7-10-19(14,2)17(16)8-11-20(18,21)3/h1,14-18,22-23H,5-13H2,2-3H3/t14-,15+,16+,17-,18-,19-,20-,21-/m0/s1
InChi Key
CKAXZOYFIHQCBN-JRRMKBMNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Cayman Chemical
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    Product Description

    HE-3235 is a synthetic adrenal hormone, an androstanediol analog, that acts as an androgen receptor antagonist.1 In an androgen receptor-dependent manner, it downregulates anti-apoptotic genes, while increasing the expression of pro-apoptotic genes, thus stimulating apoptosis.1 HE-3235 has been shown to inhibit androstenediol-dependent LNCaP cell tumor growth both in vitro (IC50 = 6 nM) and in xenograft models in vivo.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Trauger, R., Corey, E., Bell, D., et al. Inhibition of androstenediol-dependent LNCaP tumour growth by 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235). Br. J. Cancer 100(7), 1068-1072 (2009).

    2. Koreckij, T.D., Trauger, R.J., Montgomery, R.B., et al. HE3235 inhibits growth of castration-resistant prostate cancer. Neoplasia 11(11), 1216-1225 (2009).