An internal standard for the quantification of estrone
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Unlabeled Version(s)
10006485Estrone
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Estrone-d2

Item No. 9002844

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-estra-1,3,5(10)-trien-17-one-2,4-d2
CAS Number
350820-16-5
Synonyms
  • E1-d2
Molecular Formula
C18H20D2O2
Formula Weight
272.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:5): 0.15 mg/mlDMSO: 20 mg/ml
λmax
280 nm
SMILES
O=C1CC[C@@]2([H])[C@]3([H])CCC4=C([2H])C(O)=C([2H])C=C4[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1/i3D,10D
InChi Key
DNXHEGUUPJUMQT-HUQKQUBWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $41

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    1 mg

    $75

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    Product Description

    Estrone-d2 is intended for use as an internal standard for the quantification of estrone (Item No. 10006485) by GC- or LC-MS. Estrone is one of the three naturally occurring estrogens, the others being estradiol (Item Nos. ISO60155 | 10006315) and estriol (Item No. 10006484).1 Estrone is synthesized from androstenedione (Item No. 9001311) by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.1,2 Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.1 The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gruber, C.J., Tschugguel, W., Schneeberger, C., et al. Production and actions of estrogens. N. Engl. J. Med. 346(5), 340-352 (2002).

    2. Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988).