An internal standard for the quantification of estriol
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Unlabeled Version(s)
10006484Estriol
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Estriol-d2

Item No. 9002845

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
estra-1,3,5(10)-triene-2,4-d2-3,16α,17β-triol
CAS Number
53866-32-3
Synonyms
  • E3-d2
  • 16α-hydroxy-17β-Estradiol-d2
  • 1,3,5(10)-Estratriene-3,16α,17β-triol-d2
Molecular Formula
C18H22D2O3
Formula Weight
290.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
λmax
281 nm
SMILES
OC1=C([2H])C=C2C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])C[C@@H](O)[C@@H]4O)=C1[2H]
InChi Code
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1/i3D,8D
InChi Key
PROQIPRRNZUXQM-JOFMCETISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $149

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    1 mg

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    Product Description

    Estriol-d2 is intended for use as an internal standard for the quantification of estriol (Item No. 10006484) by GC- or LC-MS. Estriol is a metabolite of estradiol (Item Nos. ISO60155 | 10006315) and a major estrogen produced in the later stages of pregnancy. In a longitudinal study in healthy pregnant women, total plasma estriol levels increased from <10 ng/ml at 8-10 weeks gestation to approximately 150 ng/ml at week 38.1 The majority of the estriol synthesized in the later stages of pregnancy originates from fetal dehydroepiandrosterone sulfate (DHEAS; Item No. 15873) and serves as a direct marker of fetal adrenal gland activity.2 Saliva contains primarily unbound and unconjugated estriol and is commonly used for monitoring estriol levels.2,3 Plasma levels of estriol in males and non-pregnant females is less than 2 ng/ml.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peter, M., Dörr, H.G., and Sippell, W.G. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and at term. Horm. Res. 42(6), 278-281 (1994).

    2. Goodwin, T.M. A role for estriol in human labor, term and preterm. Am. J. Obstet. Gynecol. 180(1 Pt 3), S208-S213 (1999).

    3. Voss, H.F. Hormonal pathways of preterm birth. Am. J. Obstet. Gynecol. 180(1), S226-S231 (1999).

    4.  Steroid levels in humans. (1999).