A purine nucleoside with diverse biological activities
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2'-Deoxyguanosine (hydrate)

Item No. 9002864

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-guanosine, monohydrate
CAS Number
312693-72-4
Synonyms
  • Guanine deoxyriboside
Molecular Formula
C10H13N5O4 • H2O
Formula Weight
285.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
0.1 M HCl: 10 mg/mlDMSO: 10 mg/ml
λmax
252 nm
SMILES
NC1=NC(C(N=CN2[C@]3([H])O[C@H](CO)[C@@H](O)C3)=C2N1)=O.O
InChi Code
InChI=1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1
InChi Key
LZSCQUCOIRGCEJ-FPKZOZHISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $49

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    10 g

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    Cayman Chemical
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    Product Description

    2'-Deoxyguanosine is a purine nucleoside with diverse biological activities.1,2,3,4 It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 µM, respectively).1 2'-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 µM.2 It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems.3 2'-Deoxyguanosine (>1 µM) also induces relaxation of precontracted isolated bovine lingual artery.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ross, D.D., Akman, S.A., Schrecker, A.W., et al. Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools. Cancer Res. 41(11 Pt 1), 4493-4498 (1981).

    2. Mitchell, B.S., Mejias, E., Daddona, P.E., et al. Purinogenic immunodeficiency diseases: Selective toxicity of deoxyribonucleosides for T cells. Proc. Natl. Acad. Sci. USA 75(10), 5011-5014 (1978).

    3. Brulfert, A., Clain, E., and Deysson, G. Deoxyguanosine, a potent cytokinesis inhibitor in plant cells. Experientia 30(9), 1010-1011 (1974).

    4. Scholar, E.M. Effect of deoxypurine and deoxypyrimidine compounds on the vascular responsiveness of bovine coronary and lingual arteries. J. Pharm. Pharmacol. 32(10), 726 (1980).