An AT1 receptor antagonist
Related Products
Labeled Version(s)
25419Candesartan-d4
Pro-drug Form(s)
10489Candesartan Cilexetil
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Candesartan

Item No. 9003239

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
CAS Number
139481-59-7
Synonyms
  • Candesartan M1
  • CV-11974
Molecular Formula
C24H20N6O3
Formula Weight
440.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 15 mg/ml
SMILES
O=C(C1=CC=CC2=C1N(CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3)C(OCC)=N2)O
InChi Code
InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)
InChi Key
HTQMVQVXFRQIKW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $36

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    500 mg

    $86

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    1 g

    $153

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    5 g

    $667

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    Product Description

    Candesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for recombinant human AT1, rat AT1A, and rat AT1B receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Item No. 10489).1 It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the recombinant human AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg).2 Formulations containing candesartan have been used in the treatment of hypertension and heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Inada, Y., Nakane, T., and Chiba, S. Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors. Fundam. Clin. Pharmacol. 16(4), 317-323 (2002).

    2. Shibouta, Y., Inada, Y., Ojima, M., et al. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116). J. Pharmacol. Exp. Ther. 266(1), 114-120 (1993).