An intermediate alanine metabolite of remdesivir
Related Products
Active Metabolite(s)
30469GS-441524
Parent Compound(s)
30354Remdesivir
Technical Support & Resources

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GS-704277

Item No. 9003569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-phosphono-L-alanine, P→6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
CAS Number
1911579-04-8
Molecular Formula
C15H19N6O8P
Formula Weight
442.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
246 nm
SMILES
O=P(N[C@@H](C)C(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@@](C2=CC=C3N2N=CN=C3N)(C#N)O1
InChi Code
InChI=1S/C15H19N6O8P/c1-7(14(24)25)20-30(26,27)28-4-9-11(22)12(23)15(5-16,29-9)10-3-2-8-13(17)18-6-19-21(8)10/h2-3,6-7,9,11-12,22-23H,4H2,1H3,(H,24,25)(H2,17,18,19)(H2,20,26,27)/t7-,9+,11+,12+,15-/m0/s1
InChi Key
IYHPTSNEWCZBDF-NIFWRESRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $336

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    Cayman Chemical
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    Product Description

    GS-704277 is an intermediate alanine metabolite of the antiviral prodrug remdesivir (Item No. 30354).1,2 It is formed from remdesivir via intracellular hydrolysis. GS-704277 is further metabolized to the nucleoside monophosphate form and then to the nucleoside analog GS-441524 (Item No. 30469) or active nucleoside triphosphate GS-443902.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Humeniuk, R., Mathias, A., Cao, H., et al. Safety, tolerability, and pharmacokinetics of remdesivir, an antiviral for treatment of COVID-19, in healthy subjects. Clin. Transl. Sci. 13(5), 896-906 (2020).

    2. Eastman, R.T., Roth, J.S., Brimacombe, K.R., et al. Remdesivir: A review of its discovery and development leading to emergency use authorization for treatment of COVID-19. ACS Cent. Sci. 6(5), 672-683 (2020).