A phthalide with antiplatelet and neuroprotective activities
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L-3-n-Butylphthalide

Item No. 9003759

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3S-butyl-1(3H)-isobenzofuranone
CAS Number
3413-15-8
Synonyms
  • (–)-3-Butylphthalide
  • levo-3-n-Butylphthalide
  • (S)-(–)-3-Butylphthalide
  • L-NBP
Molecular Formula
C12H14O2
Formula Weight
190.2
Purity
≥90%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlEthanol: 10 mg/ml
SMILES
CCCC[C@H]1C2=CC=CC=C2C(O1)=O
InChi Code
InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-7,11H,2-3,8H2,1H3/t11-/m0/s1
InChi Key
HJXMNVQARNZTEE-NSHDSACASA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

    $317

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    10 mg

    $553

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    Product Description

    L-3-n-Butylphthalide is a phthalide that has been found in A. graveolens and has antiplatelet and neuroprotective activities.1 It inhibits ADP-, collagen-, and arachidonic acid-induced platelet aggregation ex vivo when administered at doses ranging from 3 to 100 mg/kg and inhibits thrombus formation in a collagen and epinephrine-induced rat model of experimental thrombosis. L-3-n-Butylphthalide (10 and 30 mg/kg per day) reduces amyloid-β-induced decreases in glutathione peroxidase (GPX) activity and decreases malondialdehyde (MDA) levels in the cortex and hippocampus and improves spatial learning and memory in the Morris water maze in a rat model of Alzheimer’s disease induced by intracerebroventricular infusion of amyloid-β (1-40) (Item No. 21617).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peng, Y., Zeng, X., Feng, Y., et al. Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in rats. J. Cardiovasc. Pharmacol. 43(6), 876-881 (2004).

    2. Peng, Y., Xing, C., Xu, S., et al. L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur. J. Pharmacol. 621(1-3), 38-45 (2009).