An internal standard for the quantification of L-isoleucine
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L-Isoleucine-13C6

Item No. 9004090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-isoleucine-1,2,3,3′,4,5-13C6
CAS Number
201740-82-1
Synonyms
  • L-(+)-Isoleucine-13C6
Molecular Formula
[13C]6H13NO2
Formula Weight
137.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[13CH3][13CH2][13C@H]([13CH3])[13C@H](N)[13C](O)=O
InChi Code
InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1
InChi Key
AGPKZVBTJJNPAG-CPLGCGHPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $86

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    10 mg

    $154

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    25 mg

    $343

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    50 mg

    $598

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    Product Description

    L-Isoleucine-13C6 is intended for use as an internal standard for the quantification of L-isoleucine by GC- or LC-MS. L-Isoleucine is an essential and branched-chain amino acid.1 It is an isomer of L-leucine (Item No. 34342) and a diastereomer of L-alloisoleucine (Item No. 34904) that functions as a nitrogen donor and has roles in glucose consumption, fatty acid metabolism, and immune function.1,2 Urinary levels of L-isoleucine are increased in patients with deficiencies in β-ketothiolase, short/branched-chain specific acyl-CoA dehydrogenase (SBCAD), or 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD), inborn errors of metabolism characterized by episodic ketoacidosis and neurological impairments.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nie, C., He, T., Zhang, W., et al. Branched chain amino acids: Beyond nutrition metabolism. Int. J. Mol. Sci. 19(4), 954 (2018).

    2. Zhang, S., Zeng, X., Ren, M., et al. Novel metabolic and physiological functions of branched chain amino acids: A review. J. Anim. Sci. Biotechnol. 8, 10 (2017).

    3. Korman, S.H. Inborn errors of isoleucine degradation: A review. Mol. Genet. Metab. 89(4), 289-299 (2006).