A bis-allylic-deuterated form of EPA
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Eicosapentaenoic Acid-d10

Item No. 9004864

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic-7,7,10,10,13,13,16,16,19,19-d10 acid
Synonyms
  • C20:5(5Z,8Z,11Z,14Z,17Z)-d10
  • C20:5-d10 n-3
  • EPA-d10
  • FA 20:5-d10
  • Timnodonic Acid-d10
Molecular Formula
C20H20D10O2
Formula Weight
312.5
Purity
≥95%
Formulation (Request formulation change)
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/ml
SMILES
OC(CCC/C=C\C([2H])([2H])/C=C\C([2H])([2H])/C=C\C([2H])([2H])/C=C\C([2H])([2H])/C=C\C([2H])([2H])C)=O
InChi Code
InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-/i2D2,5D2,8D2,11D2,14D2
InChi Key
JAZBEHYOTPTENJ-REVZQTCTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $350

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    1 mg

    $525

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    5 mg

    $1,925

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    Product Description

    Eicosapentaenoic acid-d10 (EPA-d10) is an oxidation-resistant form of EPA that is deuterated at its bis-allylic sites, which are the targets of lipid peroxidation.1,2 The substitution of deuterium for hydrogen atoms in fatty acids at bis-allylic sites can reduce lipid peroxidation at those sites by decreasing the rate of hydrogen abstraction, an effect known as the kinetic isotope effect.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Demidov, V.V. Site-specifically deuterated essential lipids as new drugs against neuronal, retinal and vascular degeneration. Drug Discov. Today 25(8), 1469-1476 (2020).

    2. Shchepinov, M.S. Polyunsaturated fatty acid deuteration against neurodegeneration. Trends Pharamacol. Sci. 41(4), 236-248 (2020).