A rare ω-3 fatty acid
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Docosatrienoic Acid

Item No. 90170

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
13Z,16Z,19Z-docosatrienoic acid
CAS Number
28845-86-5
Synonyms
  • cis-13,16,19-Docosatrienoic Acid
  • FA 22:3
Molecular Formula
C22H38O2
Formula Weight
334.5
Purity
≥98%
Formulation
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: >1 mg/mlDMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS pH 7.2: <100 µg/ml
SMILES
CC/C=C\C/C=C\C/C=C\CCCCCCCCCCCC(=O)O
InChi Code
InChI=1S/C22H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10H,2,5,8,11-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-
InChi Key
WBBQTNCISCKUMU-PDBXOOCHSA-N
Side Chain Carbon Sum
22:3
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $41

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    50 mg

    $75

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    100 mg

    $142

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    Product Description

    Docosatrienoic acid is a rare ω-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid (Item No. 9000338). Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.1 It also dose-dependently inhibits the activity of mammalian DNA polymerases and human topoisomerases I and II, potentially by binding directly to the hydrophobic region of the enzymes.2 The cis configuration of the double bonds is important for this activity, and the carboxyl group is required as the methyl ester version has no activity at these enzymes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukot. Essent. Fatty Acids 52(5), 293-297 (1995).

    2. Yonezawa, Y., Hada, T., Uryu, K., et al. Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases. Int. J. Mol. Med. 18(4), 583-588 (2006).