An esterified form of DHA
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Docosahexaenoic Acid ethyl ester

Item No. 9090310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid, ethyl ester
CAS Number
81926-94-5
Synonyms
  • C22:6(4Z,7Z,10Z,13Z,16Z,19Z) ethyl ester
  • Cervonic Acid ethyl ester
  • DHA ethyl ester
  • DHA-EE
  • Ethyl Docosahexaenoate
  • SFE 24:6
Molecular Formula
C24H36O2
Formula Weight
356.5
Purity
≥98%
Formulation (Request formulation change)
A 500 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 100 mg/mlDMSO: 100 mg/mlEthanol: 500 mg/mlPBS (pH 7.2): 0.1 mg/ml
SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(OCC)=O
InChi Code
InChI=1S/C24H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26-4-2/h5-6,8-9,11-12,14-15,17-18,20-21H,3-4,7,10,13,16,19,22-23H2,1-2H3/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-
InChi Key
ITNKVODZACVXDS-YNUSHXQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $49

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    100 mg

    $93

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    500 mg

    $306

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    1 g

    $516

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    Product Description

    Docosahexaenoic acid (DHA) ethyl ester is an esterified form of the ω-3 fatty acid DHA (Item Nos. 90310 | 17950). DHA ethyl ester increases plasma and erythrocyte membrane DHA levels in rats without altering the content of the ω-6 fatty acid arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) when administered in the diet at a dose equivalent to 8 mg/kg of DHA.1 DHA ethyl ester (300 mg/kg per day) reduces the number of reference memory errors in an eight-arm radial maze in 100-week old rats.2 Formulations containing DHA ethyl ester, in combination with EPA ethyl ester, have been used as adjuncts in the treatment of hypertriglyceridemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Valenzuela, A., Valenzuela, V., Sanhueza, J., et al. Effects of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in rats. Ann. Nutr. Metab. 49(1), 49-53 (2005).

    2. Gamoh, S., Hashimoto, M., Hossain, S., et al. Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. Clin. Exp. Pharmacol. Physiol. 28(4), 266-270 (2001).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).

    Huang, C.B., and Ebersole, J.L. A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives. Mol. Oral Microbiol. 25(1), 75-80 (2010).