Pricing updated 2015-10-13. Prices are subject to change without notice.
XLR11 is an aminoalkylindole synthetic cannabinoid that features a terminal fluorination of the N-pentyl indole. It is the 5-fluoro analog of UR-144 (Item Nos. ISO00055|ISO60055|15032). The tetramethylcyclopropyl group reportedly confers selectivity for the peripheral CB2 receptor over the central CB1 receptor.1 The N-(5-fluoropentyl) chain generally increases potency of CB1 receptor activation.2,3 XLR11 binds to CB1 and CB2 receptors with Ki values of 24 and 2.1 nM, respectively, whereas UR-144 was first reported to bind to CB1 and CB2 receptors with Ki values of 150 and 1.8 nM, respectively.1,3,4 In in vitro functional assays, XLR11 demonstrates agonist activity at the human CB1 receptor with an EC50 value of 98 nM, whereas UR-144 activates the receptor with an EC50 value of 421 nM.3 This product is intended for forensic and research applications.
|Formulation||A crystalline solid|
|λmax||217, 246, 304 nm|
WARNING - This product is not for human or veterinary use.
|Shipping||Wet ice in continental US; may vary elsewhere|
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Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-
2. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives. PCT/US00/28832 1-25 (2001 Apr 26).
Banister, S.D., Stuart, J., Kevin, R.C., et al. Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-
4. Gurney, S.M.R., Scott, K.S., Kacinko, S.L., et al. Pharmacology, toxicology, and adverse effects of synthetic cannabinoid drugs. Forensic Sci Rev 26 53 (2014).
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