Item № 11565
CAS № 1364933-54-9
Purity ≥98%
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10 mg $140.00 $0.00
25 mg $298.00 $0.00
50 mg $525.00 $0.00

Pricing updated 2015-11-30. Prices are subject to change without notice.

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  • 5-FUR-144
  • 5-fluoro UR-144

XLR11 is an aminoalkylindole synthetic cannabinoid that features a terminal fluorination of the N-pentyl indole. It is the 5-fluoro analog of UR-144 (Item Nos. ISO00055|ISO60055|15032). The tetramethylcyclopropyl group reportedly confers selectivity for the peripheral CB2 receptor over the central CB1 receptor.1 The N-(5-fluoropentyl) chain generally increases potency of CB1 receptor activation.2,3 XLR11 binds to CB1 and CB2 receptors with Ki values of 24 and 2.1 nM, respectively, whereas UR-144 was first reported to bind to CB1 and CB2 receptors with Ki values of 150 and 1.8 nM, respectively.1,3,4 In in vitro functional assays, XLR11 demonstrates agonist activity at the human CB1 receptor with an EC50 value of 98 nM, whereas UR-144 activates the receptor with an EC50 value of 421 nM.3 This product is intended for forensic and research applications.

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RESTRICTED PRODUCT This product is a controlled substance and special processing is required before shipping.
WARNING - This product is not for human or veterinary use.
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Technical Information
Formal Name (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
CAS Number 1364933-54-9
  • 5-FUR-144
  • 5-fluoro UR-144
Molecular Formula C21H28FNO
Formula Weight 329.5
Purity ≥98%
Formulation A crystalline solid
λmax 217, 246, 304 nm
InChI Code 1S/C21H28FNO/c1-20(2)19(21(20,3)4)18(24)16-14-23(13-9-5-8-12-22)17-11-7-6-10-15(16)17/h6-7,10-11,14,19H,5,8-9,12-13H2,1-4H3

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activity. J Med Chem 53 295-315 (2010).

2. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives. PCT/US00/28832 1-25 (2001 Apr 26).

3. Banister, S.D., Stuart, J., Kevin, R.C., et al. Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135. ACS Chem Neurosci 6 1445-1458 (2015).

4. Gurney, S.M.R., Scott, K.S., Kacinko, S.L., et al. Pharmacology, toxicology, and adverse effects of synthetic cannabinoid drugs. Forensic Sci Rev 26 53 (2014).

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