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Labeled Version(s)
22093Rapamycin-d3
Pro-drug Form(s)
13671Wortmannin-Rapamycin Conjugate
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Rapamycin

Item No. 13346

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
53123-88-9
Synonyms
  • AY 22989
  • NSC 226080
  • Sirolimus
  • Wy 090217
Formula Weight
914.2
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 0.25 mg/ml
λmax
268, 278, 289 nm
SMILES
O=C([C@]1([H])CCCCN1C(C([C@@]2(O)[C@H](C)CC[C@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@H](C3)C)([H])O2)=O)=O)O[C@](CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@@H]3C)=O)=O)([H])[C@H](C)C[C@H]4C[C@@H](OC)[C@H](O)CC4
InChi Code
InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChi Key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Origin
Bacterium/Streptomyces hygroscopicus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Citations

    Chen, J., Wang, Q., Feng, X., et al. Umbilical cord-derived mesenchymal stem cells suppress autophagy of T cells in patients with systemic lupus erythematosus via transfer of mitochondria. Stem Cells Int. 2016, 4062789 (2016).

    Reinke, E.N., Ekoue, D.N., Bera, S., et al. Translational regulation of GPx-1 and GPx-4 by the mTOR pathway. PLOS One 9(4), e93472 (2014).

    Gharibi, B., Ghuman, M.S., and Hughes, F.J. Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRβ-induced MSC self-renewal. J. Cell. Mol. Med. 16(11), 2789-2801 (2012).

    Kapoor, V., Zaharieva, M.M., Das, S.N., et al. Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt-mTOR signaling pathway in oral squamous cell carcinoma. Cancer Lett. 319(1), 39-48 (2012).

    Lu, C.-H., Liu, Y.-W., Hua, S.-C., et al. Autophagy induction of reversine on human follicular thyroid cancer cells. Biomed. Pharmacother. 66(8), 642-647 (2012).

    Zhang, Y., Xu, S., Lin, J., et al. mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo. Breast Cancer Res. Treat. 136(2), 379-388 (2012).