As Δ⁹-THC remains a controlled substance in almost all countries, new avenues are opening for the other non-regulated Cannabis constituents. Much is still left to be uncovered in knowing how Cannabis stimulates the endocannabinoid system in the body and to substantiate its anecdotal and scientific merits as a potential therapeutic. Cayman continues to keep an eye on the horizon by supporting law enforcement agencies in the quick identification of illicit synthetic cannabinoids, legal Cannabis industry purveyors in the safe manufacture of their products, and basic science researchers in the pursuit of understanding the endocannabinoid system and how it is affected by Cannabis.