A prodrug form of tafluprost (free acid) and a PGF2α derivative
Related Products
Active Metabolite(s)
10005439Tafluprost (free acid)
API Version(s)
26158GMP Tafluprost
Labeled Version(s)
9002405Tafluprost-d4
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Tafluprost

Item No. 10005440

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid, 1-methylethyl ester
CAS Number
209860-87-7
Synonyms
  • AFP-168
Molecular Formula
C25H34F2O5
Formula Weight
452.5
Purity
≥98%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
269 nm
SMILES
O[C@@H](C[C@@H](O)[C@@H]1/C=C/C(F)(F)COC2=CC=CC=C2)[C@@H]1C/C=C\CCCC(OC(C)C)=O
InChi Code
InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1
InChi Key
WSNODXPBBALQOF-VEJSHDCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $218

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    10 mg

    $382

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    25 mg

    $818

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    Product Description

    Tafluprost is a prodrug form of the FP receptor agonist tafluprost (free acid) (Item No. 10005439) and a derivative of prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020).1 It decreases pupillary diameter in cats when applied topically at doses of 0.0001 or 0.001% v/v. Ocular administration of tafluprost (0.0005% v/v) reduces intraocular pressure in normotensive monkeys. Formulations containing tafluprost have been used in the treatment of open-angle glaucoma and ocular hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakajima, T., Matsugi, T., Goto, W., et al. New fluoroprostaglandin F2α derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents. Biol. Pharm. Bull. 26(12), 1691-1695 (2003).