An internal standard for the quantification of tafluprost
Related Products
Unlabeled Version(s)
10005440Tafluprost
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Tafluprost-d4

Item No. 9002405

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid-d4, 1-methylethyl ester
Synonyms
  • AFP-168-d4
Molecular Formula
C25H30D4F2O5
Formula Weight
456.6
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
O[C@@H](C[C@@H](O)[C@@H]1/C=C/C(F)(F)COC2=CC=CC=C2)[C@@H]1C/C=C\C([2H])([2H])C([2H])([2H])CC(OC(C)C)=O
InChi Code
InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1/i4D2,9D2
InChi Key
WSNODXPBBALQOF-INPMSDDOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 µg

    $44

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    100 µg

    $84

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    500 µg

    $344

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    1 mg

    $600

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    Product Description

    Tafluprost-d4 is intended for use as an internal standard for the quantification of tafluprost (Item No. 10005440) by GC- or LC-MS. Tafluprost is a prodrug form of the FP receptor agonist tafluprost (free acid) (Item No. 10005439) and a derivative of the prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020).1 It decreases pupillary diameter in cats when applied topically at doses of 0.0001 or 0.001% v/v.1 Ocular administration of tafluprost (0.0005% v/v) reduces intraocular pressure in normotensive monkeys.1 Formulations containing tafluprost have been used in the treatment of open-angle glaucoma and ocular hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakajima, T., Matsugi, T., Goto, W., et al. New fluoroprostaglandin F2α derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents. Biol. Pharm. Bull. 26(12), 1691-1695 (2003).