For immunochemical detection of CB1 receptor
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Applicable for Use with
10006591CB1 Receptor (C-Term) Blocking Peptide
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CB1 Receptor (C-Term) Polyclonal Antibody

Item No. 10006590

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cannabinoid Receptor 1
Immunogen
Synthetic peptide from the C-terminal region of human protein CB1 receptor
Formulation (Request formulation change)
Peptide affinity-purified IgG
Storage Buffer
PBS, pH 7.2 with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
IF, IHC, WB
Species Reactivity
(+) Human(+) Mouse(+) Rat
UniProt Accession №
P21554
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    The CB1 receptor is a G-protein coupled receptor that binds the active component of cannabis, Δ9-tetrahydrocannabinol. This antibody has been raised against the C-terminal (amino acids 461-472) intracellular region of the human CB1 receptor and can be used for western blotting.1,2 Human and rat CB1 receptors exhibit 97.3% homology at the amino acid level over the complete protein, and 100% homology within the peptide sequence used to make this antibody.3,4 This peptide exhibits no homology with the CB2 receptor. Based on the amino acid sequence, the CB1 receptor has a molecular weight of approximately 52,800.4 The CB1 receptor and the splice variant CB1a are localized mainly in the brain, whereas the CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hemopoietic cells.3,4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Howlett, A.C., Song, C., Berglund, B.A., et al. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Mol. Pharmacol. 53(3), 504-510 (1998).

    2. McIntosh, H.H., Song, C., and Howlett, A.C. CB1 cannabinoid receptor: Cellular regulation and distribution in N18TG2 neuroblastoma cells. Brain Res. Mol. Brain Res. 53(1-2), 163-173 (1998).

    3. Gérard, C.M., Mollereau, C., Vassart, G., et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J. 279(Pt 1), 129-134 (1991).

    4. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346(6284), 561-564 (1990).

    5. Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. The Journal of Biological Chemisty 270(8), 3726-3731 (1995).

    6. Shire, D., Calandra, B., Rinaldi-Carmona, M., et al. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. Biochim. Biophys. Acta 1307(2), 132-136 (1996).

    Product Citations

    Rhomberg, T., Rovira-Esteban, L., Vikor, A., et al. Vasoactive intestinal polypeptide-immunoractive interneurons within circuits of the mouse basolateral amygdala. J. Neurosci. 38(31), 6983-7003 (2018).

    Davis, M.I., Crittenden, J.R., Feng, A.Y., et al. The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendrom bouquets of the substantia nigra. PLoS One 13(2), e0191436 (2018).

    Maccarone, R., Rapino, C., Zerti, D., et al. Modulation of type-1 and type-2 cannabinoid receptors by saffron in a rat model of retinal neurodegeneration. PLoS One 11(11), e0166827 (2016).

    Zduniak, Z., Ziolkowski, P., Regnell, P., et al. Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers. Exp. Ther. Med. 11(4), 1227-1230 (2016).

    Hebert-Chatelain, E., Reguero, L., Puente, N., et al. . Mol. Metab. 3, 495-504 (2014).

    Benz, A.H., Renne, C., Maronde, E., et al. Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. PLoS one 9(12), e81675 (2013).

    Vicente-Sanchez, A., Sanchez-Blazquez, P., Rodriguez-Munoz, M., et al. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol. Brain 6, 42 (2013).

    van der Poorten, D., Shahidi, M., Tay, E., et al. Heptatitis C virus induces the cannabinoid receptor 1. PLoS ONE 5(9), e12841 (2010).