For immunochemical analysis of the CB1 receptor
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Applicable for Use with
10006590CB1 Receptor (C-Term) Polyclonal Antibody
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CB1 Receptor (C-Term) Blocking Peptide

Item No. 10006591

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cannabinoid Receptor 1
Amino Acids
CB1 receptor (C-Term) amino acids 461-472
Formulation (Request formulation change)
200 µg of peptide
Storage Buffer
200 µl TBS, pH 7.4, with 0.1% BSA and 0.02% sodium azide
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    To be used in conjunction with Cayman’s CB1 Receptor (C-Term) polyclonal antibody (Item No. 10006590) to block protein-antibody complex formation during immunochemical analysis of CB1 · The CB1 receptor is a G-protein coupled receptor that binds the active component of cannabis, Δ9-tetrahydrocannabinol.1,2 Human and rat CB1 receptors exhibit 97.3% homology at the amino acid level over the complete protein, and 100% homology within the peptide sequence used to make the Cayman CB1 Receptor polyclonal antibody (Item No. 10006590).3,4 This peptide exhibits no homology with the CB2 receptor. Based on the amino acid sequence, the CB1 receptor has a molecular weight of approximately 52,800.4 The CB1 receptor and the splice variant CB1a are localized mainly in the brain whereas the CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hematopoietic cells.3,4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Howlett, A.C., Song, C., Berglund, B.A., et al. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Mol. Pharmacol. 53(3), 504-510 (1998).

    2. McIntosh, H.H., Song, C., and Howlett, A.C. CB1 cannabinoid receptor: Cellular regulation and distribution in N18TG2 neuroblastoma cells. Brain Res. Mol. Brain Res. 53(1-2), 163-173 (1998).

    3. Gérard, C.M., Mollereau, C., Vassart, G., et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J. 279(Pt 1), 129-134 (1991).

    4. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346(6284), 561-564 (1990).

    5. Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. The Journal of Biological Chemisty 270(8), 3726-3731 (1995).

    6. Shire, D., Calandra, B., Rinaldi-Carmona, M., et al. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. Biochim. Biophys. Acta 1307(2), 132-136 (1996).