An inactive isomer of reversine
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Retreversine

Item No. 10006606

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-cyclohexyl-N6-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine
CAS Number
1028332-91-3
Molecular Formula
C21H27N7O
Formula Weight
393.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1.6 mg/mlDMSO: 2.5 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
263, 318 nm
SMILES
C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)c2nc[nH]c2n1
InChi Code
InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)25-21-26-19-18(22-14-23-19)20(27-21)24-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
InChi Key
GCURSAGINSDQNR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Terminal differentiation of embryonic progenitor cells to form distinct, adult tissues is the hallmark of organogenesis in complex organisms. However, in mammals including humans, this process is not readily reversible. Reversine is a 2,6-disubstituted purine derivative that was identified using a screening system based on the loss of terminal differentiation markers in C2C12 myoblast cells.1 Retreversine is an inactive control molecule, created by simply interchanging the 2 and 6-substituents on the purine ring. Retreversine is inactive at 10-fold higher concentrations than reversine in the myoblast assay.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, S., Zhang, Q., Wu, X., et al. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc. 126(2), 410-411 (2004).