A reversible inhibitor of 5-lipoxygenase
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Labeled Version(s)
26761Zileuton-d4
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Zileuton

Item No. 10006967

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea
CAS Number
111406-87-2
Synonyms
  • A 64077
Molecular Formula
C11H12N2O2S
Formula Weight
236.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:1): .5 mg/mlEthanol: 10 mg/ml
λmax
203, 230, 260, 299 nm
SMILES
CC(N(C(N)=O)O)C(S1)=CC2=C1C=CC=C2
InChi Code
InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
InChi Key
MWLSOWXNZPKENC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $24

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    10 mg

    $42

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    25 mg

    $98

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    50 mg

    $173

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    Product Description

    Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor.1 It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4; Item No. 20110) production induced by the calcium ionophore A23187 (Item No. 11016) in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50 = 0.6 µM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge.2 Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carter, G.W., Young, P.R., Albert, D.H., et al. 5-Lipoxygenase inhibitory activity of zileuton. J. Pharmacol. Exp. Ther. 256(3), 929-937 (1991).

    2. Abraham, W.M., Ahmed, A., Cortes, A., et al. The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep. Eur. J. Pharmacol. 217(2-3), 119-126 (1992).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).

    Shah, R., Farmer, L.A., Zilka, O., et al. Beyond DPPH: Use of fluorescence-enabled inhibited autoxidation to predict oxidative cell death rescue. Cell Chem. Biol. 26(11), 1594-1607 (2019).

    Conrad, M., and Pratt, D.A. The chemical basis of ferroptosis. Nat. Chem. Biol. 15(12), 1137-1147 (2019).