An internal standard for the quantification of zileuton
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Unlabeled Version(s)
10006967Zileuton
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Zileuton-d4

Item No. 26761

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-benzo[b]thien-2-ylethyl-d4)-N-hydroxy-urea
CAS Number
1189878-76-9
Molecular Formula
C11H8D4N2O2S
Formula Weight
240.3
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: very slightly soluble
SMILES
ON(C(N)=O)C(C([2H])([2H])[2H])([2H])C1=CC2=CC=CC=C2S1
InChi Code
InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)/i1D3,7D
InChi Key
MWLSOWXNZPKENC-CWIRFKENSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $253

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    Product Description

    Zileuton-d4 is intended for use as an internal standard for the quantification of zileuton (Item No. 10006967) by GC- or LC-MS. Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor.1 It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4; Item No. 20110) production induced by the calcium ionophore A23187 (Item No. 11016) in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50 = 0.6 µM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge.2 Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carter, G.W., Young, P.R., Albert, D.H., et al. 5-Lipoxygenase inhibitory activity of zileuton. J. Pharmacol. Exp. Ther. 256(3), 929-937 (1991).

    2. Abraham, W.M., Ahmed, A., Cortes, A., et al. The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep. Eur. J. Pharmacol. 217(2-3), 119-126 (1992).