A metabolite of tolbutamide
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Parent Compound(s)
19888Tolbutamide
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4-hydroxy Tolbutamide

Item No. 10008520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(butylamino)carbonyl]-4-(hydroxymethyl)-benzenesulfonamide
CAS Number
5719-85-7
Molecular Formula
C12H18N2O4S
Formula Weight
286.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
229 nm
SMILES
CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1
InChi Code
InChI=1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
InChi Key
SJRHYONYKZIRPM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $46

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    5 mg

    $169

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    10 mg

    $315

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    25 mg

    $730

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    4-hydroxy Tolbutamide is a metabolite of the potassium channel antagonist tolbutamide (Item No. 19888).1 It is formed from tolbutamide by the cytochrome P450 (CYP) isoform CYP2C9 in human liver microsomes and COS-7 cell lysates expressing the human enzyme. 4-hydroxy Tolbutamide has been used as a marker of CYP2C9 activity in rat hepatocytes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miners, J.O., and Birkett, D.J. Use of tolbutamide as a substrate probe for human heptic cytochrome P450 2C9. Methods Enzymol. 272, 139-145 (1996).

    2. Nguyen, V., Espiritu, M., and Elbarbry, F. Development and validation of a sensitive and specific LC-MS/MS cocktail assay for CYP450 enzymes: Application to study the effect of catechin on rat hepatic CYP activity. Biomed. Chromatogr. 34(3), e4789 (2019).