A CB1 inverse agonist
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CAY10508

Item No. 10008669

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione
CAS Number
878533-35-8
Molecular Formula
C21H14Br2N2O2
Formula Weight
486.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.25 mg/mlDMSO: 10 mg/ml
λmax
248 nm
SMILES
Brc1ccc(cc1)N1C(=O)C(c2ccccc2)N(c2ccc(Br)cc2)C1=O
InChi Code
InChI=1S/C21H14Br2N2O2/c22-15-6-10-17(11-7-15)24-19(14-4-2-1-3-5-14)20(26)25(21(24)27)18-12-8-16(23)9-13-18/h1-13,19H
InChi Key
ROASQEPZAKGACK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $31

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    10 mg

    $55

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    25 mg

    $129

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    50 mg

    $228

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    Product Description

    CAY10508 is a potent and selective central cannabinoid (CB1) receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM.1 A 10 µM concentration of CAY10508 resulted in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and peripheral cannabinoid (CB2) receptors, respectively. A [35S]-GTPγS binding assay revealed the inverse agonist properties of CAY10508 at the CB1 receptor.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muccioli, G.G., Wouters, J., Charlier, C., et al. Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: Characterization of new CB1 cannabinoid receptor inverse agonists/antagonists. J. Med. Chem. 49(3), 872-882 (2006).