A metabolite of paclitaxel
Related Products
Labeled Version(s)
409266α-hydroxy Paclitaxel-d5
Parent Compound(s)
10461Paclitaxel
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6α-hydroxy Paclitaxel

Item No. 10009027

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,βS)-β-(benzoylamino)-α-hydroxy-benzenepropanoic acid, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2aR,3S,4R,4aS,5,6R,9S,10,11S,12S,12aR,12bS-dodecahydro-3,4,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
CAS Number
153212-75-0
Synonyms
  • 6α-hydroxy Taxol
Molecular Formula
C47H51NO15
Formula Weight
869.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlMethanol: 10 mg/ml
λmax
228 nm
SMILES
O[C@@H](C(O[C@H]1C[C@]([C@H]2OC(C3=CC=CC=C3)=O)(O)C(C)(C)C([C@@H](OC(C)=O)C([C@@]4(C)[C@@]2([H])[C@](OC(C)=O)(CO5)[C@H]5[C@@H](O)[C@@H]4O)=O)=C1C)=O)[C@@H](NC(C6=CC=CC=C6)=O)C7=CC=CC=C7
InChi Code
InChI=1S/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,5
InChi Key
NDCWHEDPSFRTDA-FJMWQILYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

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    Product Description

    6α-hydroxy Paclitaxel is a metabolite of the antimitotic and anticancer agent paclitaxel (Item No. 10461).1 It is formed from paclitaxel by the cytochrome P450 (CYP) isoform CYP2C8.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, G.N., Oatis, J.E., Jr., Thornburg, K.R., et al. 6 alpha-Hydroxytaxol: Isolation and identification of the major metabolite of taxol in human liver microsomes. Drug Metab. Dispos. 22(1), 177-179 (1994).

    2. Walle, T., Kumar, G.N., McMillian, J.M., et al. Taxol metabolism in rat hepatocytes. Biochem. Pharmacol. 46(9), 1661-1664 (1993).

    Product Citations

    Lin, W., Wang, Y.-M., Chai, S.C., et al. SPA70 is a potent antagonist of human pregnane X receptor. Nat. Commun. 8(1), 741 (2017).