A stilbene and an active metabolite of trans-resveratrol
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Isomer(s)
43319MAO-A Inhibitor 1
Parent Compound(s)
70675trans-Resveratrol
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Piceatannol

Item No. 10009366

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-1,2-benzenediol
CAS Number
10083-24-6
Synonyms
  • Astringenin
  • trans-Picetannol
  • trans-3,3',4,5'-Tetrahydroxystilbene
Molecular Formula
C14H12O4
Formula Weight
244.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
221, 327 nm
SMILES
Oc1cc(\C=C/c2ccc(O)c(O)c2)cc(O)c1
InChi Code
InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
InChi Key
CDRPUGZCRXZLFL-OWOJBTEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $53

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    10 mg

    $98

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    25 mg

    $180

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    50 mg

    $332

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    Product Description

    Piceatannol is a stilbene that has been found in red wine and an active metabolite of trans-resveratrol (Item No. 70675), a polyphenol with diverse biological activities.1 It is formed from trans-resveratrol by the cytochrome P450 (CYP) isoform CYP1B1.1,2 Piceatannol induces apoptosis in BJAB B cell lymphoma cells (EC50 = 25 µM).3 Dietary administration of piceatannol (0.025% w/w) improves intestinal epithelial barrier integrity, prevents decreases in colon length, and increases body weight in a mouse model of ulcerative colitis induced by dextran sodium sulfate (DSS; Item No. 23250).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Potter, G.A., Patterson, L.H., Wanogho, E., et al. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYPIBI. Br. J. Cancer 86(5), 774-778 (2002).

    2. Rotondo, S., Rajtar, G., Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br. J. Pharmacol. 123(8), 1691-1699 (1998).

    3. Wieder, T., Prokop, A., Bagci, B., et al. Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts. Leukemia 15(11), 1735-1742 (2001).

    4. Lin, W.-S., Chueh, T.-L., Nagabhushanam, K., et al. Piceatannol and 3'-hydroxypterostilbene alleviate inflammatory bowel disease by maintaining intestinal epithelial integrity and regulating gut microbiota in mice. J. Agric. Food Chem. 71(4), 1994-2005 (2023).