An internal standard for the quantification of 9(10)-DiHOME
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Unlabeled Version(s)
53400(±)9(10)-DiHOME
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(±)9(10)-DiHOME-d4

Item No. 10009993

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)9,10-dihydroxy-12Z-octadecenoic-9,10,12,13-d4 acid
Synonyms
  • Leukotoxin diol-d4
Molecular Formula
C18H30D4O4
Formula Weight
318.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 µg/ml
SMILES
CCCCC/C([2H])=C([2H])\C[C@](O)([2H])[C@@](O)([2H])CCCCCCCC(O)=O
InChi Code
InChI=1S/C18H34O4/c1-2-3-4-5-7-10-13-16(19)17(20)14-11-8-6-9-12-15-18(21)22/h7,10,16-17,19-20H,2-6,8-9,11-15H2,1H3,(H,21,22)/b10-7-/t16-,17-/m1/s1/i7D,10D,16D,17D
InChi Key
XEBKSQSGNGRGDW-ANOCDKEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    25 µg

    $83

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    50 µg

    $158

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    100 µg

    $297

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    500 µg

    $1,073

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    Product Description

    (±)9(10)-DiHOME-d4 is intended for use as an internal standard for the quantification of 9(10)-DiHOME by GC- or LC-MS. (±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Item No. 52400), a cytochrome P450-derived epoxide of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) also known as leukotoxin.1 It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Greene, J.F., Williamson, K.C., Newman, J.W., et al. Metabolism of monoepoxides of methyl linoleate: Bioactivation and detoxification. Arch. Biochem. Biophys. 376(2), 420-432 (2000).

    2. Moghaddam, M.F., Grant, D.F., Cheek, J.M., et al. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Nat. Med. 3(5), 562-566 (1997).

    Product Citations

    Kutzner, L., Rund, K.M., Ostermann, A.I., et al. Development of an optimized LC-MS method for the detection of specialized pro-resolving mediators in biological samples. Front. Pharmacol. 10, 169 (2019).