An HMG-CoA reductase inhibitor
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Mevastatin

Item No. 10010340

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-methyl-(1S,2,3,7S,8S,8aR)-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2-H-pyran-2-yl]ethyl]-1-naphthalenyl ester-butanoic acid
CAS Number
73573-88-3
Synonyms
  • Compactin
  • CS 500
  • L-637,312
  • ML 236B
  • NSC 281245
  • Statin I
Molecular Formula
C23H34O5
Formula Weight
390.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
236 nm
SMILES
CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12
InChi Code
InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22?/m0/s1
InChi Key
AJLFOPYRIVGYMJ-DRHLORRRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

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    50 mg

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    100 mg

    $120

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Mevastatin is a competitive HMG-CoA reductase inhibitor (Ki = 0.1 µM).1 In vivo, mevastatin (50 mg/kg) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats, as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine.2 Mevastatin also suppresses TNF-induced NF-κB activation (IC50 = ~17 µM) and potentiates apoptosis in human myeloid leukemia cells.3 It also suppresses induced ferroptosis in HT-1080 cells.4 Formulations containing mevastatin have been used in the treatment of familial hypercholesterolemia.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Endo, A., Kuroda, M., and Tanzawa, K. Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Lett. 72(2), 323-326 (1976).

    2. Fears, R., Richards, D.H., and Ferres, H. The effect of compactin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity, on cholesterogenesis and serum cholesterol levels in rats and chicks. Atherosclerosis. 35(4), 439-449 (1980).

    3. Ahn, K.S., Sethi, G., and Aggarwal, B.B. Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway. Biochem. Pharmacol. 75(4), 907-913 (2008).

    4. Conlon, M., Poltorack, C.D., Forcina, G.C., et al. A compendium of kinetic modulatory profiles identifies ferroptosis regulators. Nat. Chem. Biol. (2021).

    5. Endo, A. The discovery and development of HMG-CoA reductase inhibitors. J. Lipid Res. 33(11), 1569-1582 (1992).