A potent HMG-CoA reductase inhibitor
Related Products
Labeled Version(s)
25464Pravastatin-d3 (sodium salt)
Metabolite(s)
22572Pravastatin lactone
Parent Compound(s)
10010340Mevastatin
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Pravastatin (sodium salt)

Item No. 10010343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1S,2S,6S,7S,8R,8aR-hexahydro-βR,δR,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid, monosodium salt
CAS Number
81131-70-6
Molecular Formula
C23H35O7 • Na
Formula Weight
446.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 2.5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
238 nm
SMILES
CC[C@H](C)C(O[C@H]1C[C@H](O)C=C2[C@@]1([H])[C@@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@@H](C)C=C2)=O.[Na+]
InChi Code
InChI=1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
InChi Key
VWBQYTRBTXKKOG-IYNICTALSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin.2 It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule.2 Pravastatin, marketed as Pravachol™ or Lipostat™, is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. In a study using dogs, five weeks of treatment with a dose 20 mg/kg per day reduced total plasma cholesterol levels by 29%.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug Discov. 2(7), 517-526 (2003).

    2. Corsini, A., Maggi, F.M., and Catapano, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol. Res. 31(1), 9-27 (1995).

    Product Citations

    Shiozawa, A., Yamaori, S., Kamijo, S., et al. Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3). Drug Metab. Pharmacokinet. 36, 100364 (2021).

    Marsh, A., Casey-Green, K., Probert, F., et al. Simvastatin sodium salt and fluvastatin interact with human gap junction gamma-3 protein. PLoS One 11(2), e0148266 (2016).