A carotenoid with diverse biological activities
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Isomer(s)
10009992Zeaxanthin
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Lutein

Item No. 10010811

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6'R)-β,ε-carotene-3R,3'R-diol
CAS Number
127-40-2
Synonyms
  • E 161b
  • Xanthophyll
Molecular Formula
C40H56O2
Formula Weight
568.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 5 mg/mlDMF: 10 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 5 mg/ml
λmax
268, 445, 474 nm
SMILES
O[C@@H]1CC(C)(C)[C@@H](/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C)C[C@@H](O)CC2(C)C)C)C)C(C)=C1
InChi Code
InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-25,35-37,41-42H,26-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36+,37-/m0/s1
InChi Key
KBPHJBAIARWVSC-RGZFRNHPSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

    $47

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    10 mg

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    25 mg

    $462

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    Product Description

    Lutein is a dietary carotenoid that has been found in eggs and yellow-colored fruits and vegetables and has diverse biological activities.1,2,3,4 It reduces hyperglycemia-induced mitochondrial DNA damage and production of reactive oxygen species (ROS) and promotes mitochondrial biogenesis in ARPE-19 cells when used at a concentration of 10 µM.1 Lutein (20 mg/kg) increases nitric oxide (NO) production and decreases serum levels of endothelin-1 (Item No. 24127) in a rat model of hyperhomocysteinemia.2 Dietary administration of lutein (0.2%) decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis. Lutein reduces infarct size and cardiac malondialdehyde (MDA), lactate dehydrogenase (LDH), and troponin T levels, and increases cardiac levels of catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and Nrf2 in a rat model of heart failure induced by isoproterenol (Item No. 15592).3 It forms a retinal pigment in human eyes, and high dietary intake of lutein is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nanjaiah, H., and Vallikannan, B. Lutein upregulates the PGC-1α, NRF1, and TFAM expression by AMPK activation and downregulates ROS to maintain mtDNA integrity and mitochondrial biogenesis in hyperglycemic ARPE-19 cells and rat retina. Biotechnol. Appl. Biochem. 66(6), 999-1009 (2019).

    2. Hajizadeh-Sharafabad, F., Ghoreishi, Z., Maleki, V., et al. Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: A systematic review of in vivo, ex vivo and in vitro studies. Pharmacol. Res. 149, 104477 (2019).

    3. Ouyang, B., Li, Z., Ji, X., et al. The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway. Pharm. Biol. 57(1), 529-535 (2019).

    4. Bungau, S., Abdel-Daim, M., Tit, D.M., et al. Health benefits of polyphenols and carotenoids in age-related eye diseases. Oxid. Med. Cell. Longev. 9783429 (2019).