A polyphenol with diverse biological activities
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Hispidin

Item No. 10012605

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-4-hydroxy-2H-pyran-2-one
CAS Number
555-55-5
Molecular Formula
C13H10O5
Formula Weight
246.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: >10 mg/ml
λmax
221, 255, 379 nm
SMILES
OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O
InChi Code
InChI=1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+
InChi Key
SGJNQVTUYXCBKH-HNQUOIGGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    5 mg

    $402

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    Product Description

    Hispidin is a polyphenol originally isolated from P. hispidus that has diverse biological activities, including antioxidant, anti-inflammatory, and cytoprotective properties.1,2,3,4 In a trolox equivalent antioxidant capacity (TEAC) assay, hispidin scavenges radicals at 14.47 equivalents of trolox (Item No. 10011659).2 It inhibits transcriptional activity of NF-κB, decreases inducible nitric oxide synthase (iNOS) expression, and decreases the generation of reactive oxygen species (ROS) in LPS-induced macrophage RAW 264.7 cells.3 Hispidin inhibits apoptosis and increases insulin secretion in hydrogen peroxide-treated RINm5F pancreatic β-cells.4 It inhibits protein kinase C β (PKCβ; IC50 = 2 μM) with no activity against alkaline phosphatase.5 Hispidin also inhibits β-secretase (BACE1; IC50 = 4.9 μM) and prolyl endopeptidase (PE; IC50 = 16 μM) but not other serine proteases when used at a concentration of 40 μM (0.6, 0, 8.2, and 3.1% inhibition of chymotrypsin, trypsin, elastase, and tumor necrosis factor-α converting enzyme (TACE), respectively).6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nambudiri, A.M., Vance, C.P., and Towers, G.H. Effect of light on enzymes of phenylpropanoid metabolism and hispidin biosynthesis in Polyporus hispidus. Biochem. J. 134(4), 891-897 (1973).

    2. Zan, L.-F., Qin, J.-C., Zhang, Y.-M., et al. Antioxidant hispidin derivatives from medicinal mushroom Inonotus hispidus. Chem. Pharm. Bull. (Tokyo) 59(6), 770-772 (2011).

    3. Shao, H.J., Joeng, J.B., Kim, K.-J., et al. Anti-inflammatory activity of mushroom-derived hispidin through blocking of NF-κB activation. J. Sci. Food Agric. 95(12), 2482-2486 (2015).

    4. Jang, J.S., Lee, J.S., Lee, J.H., et al. Hispidin produced from Phellinus linteus protects pancreatic β-cells from damage by hydrogen peroxide. Arch. Pharm. Res. 33(6), 853-861 (2010).

    5. Gonindard, C. Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro. Cell Biol. Toxicol. 13(3), 141-153 (1997).

    6. Park, I.-H., Jeon, S.-Y., Lee, H.-J., et al. A β-secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus. Planta Med. 70(2), 143-146 (2004).